Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer’s Disease Patients

Table 2

Absolute and normalized hippocampal areas and volumes in Alzheimer disease patients and controls.

Hippocampal measures	AD patients	Controls	values	Cohen’s	AUC (SE)
Absolute measures (mm^2, mm^3)
Area of the optimal slice on the left			<0.01	1.91	0.91 (0.0331)
Area of the optimal slice on the right			<0.01	1.64	0.87 (0.039)
Volume on the left (FreeSurfer)			<0.01	1.2	0.86 (0.0486)
Volume on the right (FreeSurfer)			<0.01	1.16	0.83 (0.0506)
Normalized measures (%)
Area of the optimal slice on the left to brain area at anterior commissure			0.01	1.75	0.89 (0.034)
Area of the optimal slice on the right to brain area at anterior commissure			<0.01	1.46	0.85 (0.0416)
Volume on the left to TIV (FreeSurfer)			0.01	0.7	0.73 (0.061)
Volume on the right to TIV (FreeSurfer)			<0.01	0.84	0.78 (0.0551)

Absolute hippocampal areas in the optimal slice on the left and right are in mm². Absolute hippocampal volumes on the left and right are in mm³. Normalized hippocampal areas of the optimal slice to the brain area at anterior commissure on the left and right and normalized hippocampal volumes to total intracranial volume (TIV) on the left and right are in percentages. All values are expressed as ; SE means standard error of AUC (ROC).