HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016

Table 2

Demographic characteristics of treatment-experienced HIV-1 individuals with virologic failure and univariate analyses for correlates of drug resistance.

Variables	Without DR	DR	value
	Gender
Male	202 (85.6)	209 (85.3)	0.94
Female	34 (14.4)	36 (14.7)
Age (years)
15~	24 (10.2)	21 (8.6)	0.84
25~	63 (26.7)	67 (27.3)
35~	47 (19.9)	57 (23.3)
45~	33 (14.0)	36 (14.7)
≥55	69 (29.2)	64 (26.1)
Marital status
Married/cohabiting	114 (48.3)	128 (52.2)	0.70
Single	74 (31.4)	74 (30.2)
Divorced/widowed/separated	44 (18.6)	41 (16.7)
Unknown	4 (1.7)	2 (0.8)
Infection routes
Heterosexual contact	166 (70.3)	176 (71.8)	0.83
Homosexual contact	51 (21.6)	47 (19.2)
IDU	4 (1.7)	3 (1.2)
Unknown	15 (6.4)	19 (7.8)
CD4^+ T cell count (cells/μl)
≤200	78 (33.1)	177 (72.2)	0.00
>200	151 (64.0)	65 (26.5)
Unknown	7 (3.0)	3 (1.2)
Treatment duration (year)
0.5~	57 (24.2)	75 (30.6)	0.28
1~3	136 (57.6)	128 (52.2)
≥3	43 (18.2)	42 (17.1)
Treatment regimen
AZT+3TC+EFV/NVP/others	91 (38.6)	64 (26.1)	0.00
D4T+3TC+EFV/NVP/others	26 (11.0)	24 (9.8)
TDF+3TC+EFV/NVP/others	116 (49.2)	156 (63.7)
3TC+EFV+NVP	3 (1.3)	0 (0.0)
Unknown	0 (0.00)	1 (0.4)
Treatment change
Yes	8 (3.4)	17 (6.9)	0.07
No	228 (96.6)	228 (93.1)
Viral load (log10)
3~	130 (55.1)	111 (45.3)	0.10
4~	77 (32.6)	98 (40.0)
≥3	29 (12.3)	36 (14.7)
Subtypes
CRF01_AE	94 (39.8)	167 (68.2)	0.00
CRF07_BC	131 (55.5)	69 (28.1)
CRF08_BC	8 (3.4)	1 (0.4)
CRF55_01B	0 (0.0)	2 (0.8)
B	2 (0.8)	4 (1.6)
C	1 (0.4)	2 (0.8)