Low-Frequency Ultrasound Enhances Bactericidal Activity of Antimicrobial Agents against Klebsiella pneumoniae Biofilm

Figure 1

Diagram depicting using LFU and antimicrobial agents for the treatment of K. pneumoniae biofilms. Three catheter disks with biofilms were placed into each well of a 24-well plate containing 1 mL of antimicrobial agent solution. Sterile medium was added to the wells around the edge of the 24-well plate, serving as a negative control. LFU was transmitted through the bottom of the plate via sterile water. This study was to investigate the treatment effect of S-LFU or M-LFU in combination with five different types of antimicrobial agents.