Essential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells

Table 2

The IC₅₀ values of C. citratus essential oils on various lung cancer cell lines.

Essential oils^a (μg/ml)	Wild type of EGFR and TKI-resistance		Mutation of EGFR and TKI-resistance
	A549	H1299	H1650	H1975
HCL	3.84 ± 0.43	2.45 ± 0.21	6.24 ± 0.52	5.36 ± 0.27
HCC	3.77 ± 0.28	3.56 ± 0.40	6.81 ± 0.75	6.16 ± 0.54
HLL	1.73 ± 0.37	3.37 ± 0.18	7.89 ± 0.64	4.01 ± 0.30
HLC	4.50 ± 0.30	4.94 ± 0.47	8.71 ± 0.36	4.25 ± 0.53
LTL	4.98 ± 0.68	5.79 ± 0.27	6.52 ± 0.29	4.74 ± 0.07
LTC	4.40 ± 0.75	6.56 ± 0.39	8.36 ± 0.08	5.83 ± 0.25
KDL	4.25 ± 0.32	7.50 ± 0.93	6.15 ± 0.28	5.46 ± 0.93
KDC	5.28 ± 0.59	8.93 ± 0.50	4.86 ± 0.29	8.49 ± 0.68
Camptothecin^b	0.48 ± 0.02	0.49 ± 0.05	0.42 ± 0.01	0.42 ± 0.05

^aExperiments were carried out in triplicate; ^bpositive control.