Misaponin B Induces G2/M Arrest, Cytokinesis Failure and Impairs Autophagy

<div>Misaponin B exerts cytotoxicity in several cancer cells, such as A549, H460, AsPC-1, and SKOV3 cancer cells and induces G2/M arrest in A549 cells and AsPC-1 cells. (a) Chemical structure of Misaponin B (MSB). (b) Cytotoxicity of Misaponin B in several cancer cells. MTT assay was used to evaluate the cytotoxicity of Misaponin B in A549, H460, AsPC-1, and SKOV3 cells. (c, d) Effect of Misaponin B on G2/M arrest in A549 and AsPC-1 cells by FACS analysis. 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BioMed Research International

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Figure 1

Figure 1: Misaponin B Induces G2/M Arrest, Cytokinesis Failure and Impairs Autophagy 