Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study

Figure 7

Tumor suppressing pathway of citral on prostate cancer cells. Upon citral treatment, the prostate cancer cell activates phosphorylation of AMPK and inhibits fatty acid synthesis and cholesterol pathway genes such as SREBP1, ACC, FASN, and HMGR and that in turn increases the expression of BAX, downregulates Bcl-2 expression, and promotes apoptosis.