Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: <i>In Silico</i> and <i>In Vitro</i> Study

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Proteins</td><td class="align_center">Molecules</td><td class="align_center">Docking energy (Kcal/mol)</td><td class="align_center">Interaction residues</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left" rowspan="2">FASN</td><td class="align_center">Neral</td><td class="align_center">−6.3</td><td class="align_center">ILE2250, LEU2251, PHE2323, PHE2370, PHE2371, ALA2419, PHE2423</td></tr><tr><td class="align_center">Geranial</td><td class="align_center">−6.4</td><td class="align_center">LEU2222, GLU2251, PHE2370, PHE2371, PHE2375</td></tr><tr><td class="align_center" colspan="4"><hr/></td></tr><tr><td class="align_left" rowspan="2">Bcl-2</td><td class="align_center">Neral</td><td class="align_center">−5.2</td><td class="align_center">ALA97, ASP100, PHE101, TRP141, GLY142, VAL145, TYR199, PHE195, LEU198</td></tr><tr><td class="align_center">Geranial</td><td class="align_center">−5.3</td><td class="align_center">ALA97, PHE101, TYR105, TRP141, GLY142, VAL145, PHE195, LEU198, TYR199</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Molecular interaction analysis of neral and geranial against each target protein.</div>

BioMed Research International

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Table 4

Table 4: Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: <i>In Silico</i> and <i>In Vitro</i> Study 

Table 4 | Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study 