Research Article

The Blood Gene Expression Signature for Kawasaki Disease in Children Identified with Advanced Feature Selection Methods

Table 2

KEGG and GO enrichment results of the 332 genes.

CategoryFunctionFDR

KEGGhsa05164 influenza A0.012638
hsa05169 Epstein-Barr virus infection0.012638
hsa05160 hepatitis C0.012834
hsa05322 systemic lupus erythematosus0.012834
hsa05162 measles0.013912

GO BPGO:0006955 immune response7.29-22
GO:0002252 immune effector process2.36-21
GO:0006952 defense response1.09-20
GO:0002376 immune system process1.82-20
GO:0045087 innate immune response3.95-18
GO:0019221 cytokine-mediated signaling pathway9.28-17
GO:0051707 response to other organisms7.40-16
GO:0043207 response to external biotic stimulus7.40-16
GO:0009607 response to biotic stimulus3.25-15
GO:0060337 type I interferon signaling pathway6.82-14

GO MFGO:0001730 --oligoadenylate synthetase activity0.008883
GO:0003725 double-stranded RNA binding0.008883
GO:0050786 RAGE receptor binding0.02261

GO CCGO:0044433 cytoplasmic vesicle part1.54-08
GO:0031982 vesicle1.31-07
GO:0005737 cytoplasm1.59-07
GO:0044444 cytoplasmic part3.60-07
GO:0031410 cytoplasmic vesicle1.81-06
GO:0097708 intracellular vesicle1.81-06
GO:0042581 specific granule2.16-06
GO:0030141 secretory granule2.45-06
GO:0005829 cytosol4.43-06
GO:0012505 endomembrane system6.44-06

Since there were too many enriched “GO BP” and “GO CC” terms, only the top 10 terms were listed.