Untargeted Metabolomic Profiling Using UHPLC-QTOF/MS Reveals Metabolic Alterations Associated with Autism

Figure 3

Diagnostic performances of the urinary metabolite parameters in ASD. (a) ROC curve analysis: nicotinamide, anthranilic acid (vitamin L1), D-neopterin, and 7,8-dihydroneopterin as biomarkers of ASD. (b) ROC curve cross-validation based on the combined metabolic biomarker panel could significantly discriminate autism from a healthy individual. AUC: area under the ROC curve; ROC: receiver operating characteristic.

(a)

(b)