Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer

Table 1

Univariate and multivariate Cox regression analyses of overall survival in patients with colon cancer in GSE41258.

Variables	Total (%)	Univariate analysis		Multivariate analysis
		HR (95% CI)		HR (95% CI)
Age
<60	54 (32.3%)	1 (reference)
≥60	113 (67.7%)	1.239 (0.782–1.963)	0.361
Sex
Male	88 (52.7%)	1 (reference)
Female	79 (47.3%)	0.661 (0.433–1.008)	0.054
Group stage
I+II	69 (41.3%)	1 (reference)		1 (reference)
III+IV	98 (58.7%)	4.006 (2.461–6.523)	0.000	0.679 (0.275–1.679)	0.402
T stage
T1+T2	33 (19.8%)	1 (reference)		1 (reference)
T3+T4	134 (80.2%)	2.531 (1.312–4.884)	0.006	1.219 (0.607–2.446)	0.578
N stage
N0	84 (50.3%)	1 (reference)		1 (reference)
N1+N2	83 (49.7%)	2.361 (1.550–3.597)	0.000	2.572 (1.292–5.119)	0.007
M stage
No	114 (68.3%)	1 (reference)		1 (reference)
Yes	53 (31.7%)	9.878 (6.295–15.500)	0.000	11.195 (5.949–21.070)	0.000
P53 mutant
Wild type	46 (27.5%)	1 (reference)
Mutant	83 (49.7%)	1.118 (0.696–1.795)	0.646
Missing	39 (23.4%)

Characteristics with significant values after univariate analysis were screened by multivariate analysis. HR: hazard ratio; CI: confidence interval; TNM: tumor-node-metastasis.