Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer

Table 2

Univariate and multivariate Cox regression analyses of overall survival in patients with colon cancer in TCGA.

Variables	Total n(%)	Univariate analysis		Multivariate analysis
		HR (95% CI)		HR (95% CI)
Age
<60	124 (29.0%)	1 (reference)
≥60	304 (71.0%)	1.224 (0.762–1.966)	.404
Sex
Male	230 (53.7%)	1(reference)
Female	198 (46.3%)	0.830 (0.547–1.259)	0.380
TNM stage
I+II	235 (54.9%)	1 (reference)		1 (reference)
III+IV	182 (42.5%)	3.318 (2.102–5.238)	0.000	3.018 (0.973–9.362)	0.056
Missing	11 (2.6%)
T stage
T1+T2	84 (19.6%)	1 (reference)		1 (reference)
T3+T4	343 (80.1%)	3.741 (1.515–9.241)	0.005	4.555 (1.087–19.083)	0.038
Missing	1 (0.2%)
N stage
N0	251 (58.6%)	1 (reference)		1 (reference)
N1+N2	177 (41.4%)	2.824 (1.841–4.332)	0.000	0.628 (0.239–1.502)	0.345
M stage
M0	316 (73.8%)	1 (reference)		1 (reference)
M1	61 (14.3%)	4.933 (3.101–7.848)	0.000	2.652 (1.502–4.685)	0.001
Missing	51 (11.9%)

Characteristics with significant values after univariate analysis were screened by multivariate analysis. HR: hazard ratio; CI: confidence interval; TNM: tumor-node-metastasis.