Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat

Figure 2

Typical examples of cystometry under anesthesia with urethane and 32 mg/kg sodium pentobarbital. Micturition could be observed in the urethane group (a) and 32 mg/kg pentobarbital group (b). (c) and (d) shows tonic EUS-EMG activity shifted to a bursting pattern at the peak of the bladder contraction in the urethane and 32 mg/kg pentobarbital groups. Top, cystometrogram; middle, EUS-EMG activity during filling and voiding; bottom, EUS bursting activity during voiding in faster time phase. EUS-EMG: external urethral sphincter electromyography; ICI: intercontraction interval; PT: pressure threshold; RP: resting pressure; MIVP: maximum intravesical pressure; CD: contraction duration; ET: expulsion time; i.p.: intraperitoneal injection.

(a)

(b)

(c)

(d)