Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat

Figure 3

Typical examples of cystometry under anesthesia with 36 and 40 mg/kg sodium pentobarbital. Micturition could not be observed in the 36 mg/kg group (a) and 40 mg/kg pentobarbital group (b). (c) and (d) shows increased tonic EUS-EMG activity during a nonvoiding contraction with a bladder leak response in the 36 mg/kg and 40 mg/kg pentobarbital groups. Top, cystometrogram; middle, EUS-EMG activity during filling and nonvoiding contraction; bottom, EUS bursting activity during nonvoiding contraction in faster time phase. EUS-EMG: external urethral sphincter electromyography; i.p.: intraperitoneal injection.

(a)

(b)

(c)

(d)