Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach

Figure 4

Binding complex and interaction visualization between falcipain 2 (3BPF, light purple), hydroxycarboxyethyl-carbonyl [leucylamino-butyl]-guanindine (E64, green), and isoquinoline derivative (ISO, yellow). In the ISO-E64-3BPF binding complex (a), E64 and ISO share the different binding pockets. Interaction visualization of E64-3BPF (b) shows mostly different residue interactions with ISO-3BPF (c).

(a)

(b)

(c)