Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach

Figure 8

Binding complex and interaction visualization between dihydrofolate reductase, thymidylate synthase (2BLA, dark purple), pyrimethamine (CP6, green), and isoquinoline derivative (ISO, yellow). In the ISO-CP6-2BLA binding complex (a), CP6 and ISO share the same binding pocket. Interaction visualization of CP6-2BLA (b) shows a few similar hydrophobic interactions with ISO-2BLA (c).

(a)

(b)

(c)