No. Protein target PDB ID Res (Å) Organism Native ligand Percent identity to human protein (accession no.) [17 , 18 ] Ref. 1. Pf dUTPDXRaseDeoxyuridine 5′-triphosphate nucleotidohydrolase 1VYQ 2.40 P . falciparum 2,3-Deoxy-3-fluoro-5-O-trityluridine (DUX) 36.59% 1Q5H_A [16 , 19 ] 2. Pf DHODHDihydroorotate dehydrogenase 3O8A 2.30 P . falciparum N-Cyclopropyl-5-[2-methyl-5-(trifluoromethoxyl)-1H-benzimidazol-1-yl]thiophene-2-carboxamide (O8A) 38.52% 5K9C_A [20 ] 3. Pv DHFRDihydrofolate reductase-thymidylate synthase 2BLA 2.50 P . vivax Pyrimethamine (CP6) 28.71% 3GHV_A [21 –23 ] 4. Pf PMTPhosphoethanolamine N-methyltransferase 4FGZ 1.994 P . falciparum Amodiaquine, flavoquine (CQA) 45.83% 3O0Z_A [16 , 24 , 25 ] 5. Pf AdSSAdenylosuccinate synthetase 1P9B 2.00 P . falciparum Hadacidin (HDA) 46.03% 2V40_A [16 , 26 , 27 ] 6. Pf GKGlycerol kinase 2W41 2.41 P . falciparum Adenine diphosphate (ADP) 41.67% 2GY5_A [16 , 28 ] 7. GMP synthetase Guanosine monophosphate synthetase 3UOW 2.72 P . falciparum Xanthosine monophosphate (XMP) 30.77% 2VXO_A [16 , 29 ] 8. Pf ENREnoyl-acyl carrier protein reductase 3LT0 1.96 P . falciparum 4-(2,4-Dichlorophenoxy)-3-hydroxybenzaldehyde (FT1); nicotinamide-adenine-dinucleotide (NAD) 30.00% 6JLQ_A [16 ,30 –32 ] 9. Pf G6PIGlucose-6-phosphate isomerase 3PR3 2.45 P . falciparum Fructose-6-phosphate (F6P) 38.89% 1JLH_A [16 , 33 , 34 ] 10. Pf -cTrpRNATryptophanyl tRNA synthetase 4J75 2.40 P . falciparum Tryptophanyl-5′amp (TYM) 50.25% 1ULH_A [16 , 35 , 36 ] 11. DXR 1-Deoxy-D-xylulose 5-phosphate reductoisomerase 4Y67 1.60 P . falciparum [(2R)-2-{2-[Hydroxy(methyl)amino]-2-oxoethyl}-5-phenylpentyl]phosphonic acid (RC5) 28.57% 3FJC_A [16 , 37 , 38 ] 12. DXR 1-Deoxy-D-xylulose 5-phosphate reductoisomerase 3AU9 1.90 P . falciparum 3-[Formyl(hydroxyl)amino]propylphosphonic (fosmidomycin/FOM) 28.57% 3FJC_A [39 ] 13. FP2 Falcipain 2 3BPF 2.90 P . falciparum N-[N-[1-Hydroxycarboxyethyl-carbonyl]leucylamino-butyl]-guanindine (E64) 38.50% 1FH0_A [6 ,40 –42 ] 14. FP3 Falcipain 3 3BWK 2.42 P . falciparum N∼2∼-(Morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-phenylsulfonyl)pentan-3-yl)]-L-leucinamide (C1P) 78.00% 4AHH_A [6 , 40 , 43 ]