Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model

Figure 1

(a) The mandibular right premolar 4 (PM4) was extracted with flap elevation as atraumatically as possible. (b) The sockets were filled with anorganic bovine bone mineral with 10% collagen (ABBM-C) functionalized with either anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb, test group) or isotype matched control mAb (control group). (c) The sockets filled with ABBM-C were covered by porcine bilayer native collagen membrane (CM) functionalized with either anti-BMP-2 mAb or isotype matched control mAb. The marginal gingiva was then approximated to achieve primary wound closure with a nonresorbable suture.

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(b)

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