Valuable Role of Neutrophil CD64 and Highly Sensitive CRP Biomarkers for Diagnostic, Monitoring, and Prognostic Evaluations of Sepsis Patients in Neonatal ICUs

Table 4

The diagnostic performance of studied sepsis biomarkers.

	Cutoff value	Specificity (%)	Sensitivity(%)	NPV (%)	PPV (%)	Eff (%)	AUC
CD64%	0.43	93%	85.6%	68.3%	97.5%	87.5%	0.922
hs-CRP (mg/L)	3.0	80%	73.3%	50%	91.7%	75%	0.772
CD64 MFI	1.445	50.0%	73.3%	38.5%	81.5%	68.0%	0.675
TLC (×10^9/L)	14.7	53%	51.1%	26.7%	76.7%	51.6%	0.561
ANC (×10^9/L)	5	52.9%	67.5%	26.5%	86.7%	64.9%	0.684
ratio	<0.2	100.0%	25.7%	49.0%	100.0%	56.7%	0.779
Blood culture	+ve results	90.0%	50.0%	37.5%	93.8%	60.0%	—
CD64% & hs-CRP (mg/L)		100%	91.2%	78.9%	100%	93.4%	0.988

Eff.: efficacy; NPV: negative predictive value; PPV: positive predicted value.