Fractionated Stereotactic Radiation Therapy Using Volumetric Modulated Arc Therapy in Patients with Solitary Brain Metastases

Table 3

Adverse events.

Adverse events	Grade 1	Grade 2	Grade 3	Grade 4
Nausea	5 (11%)	4 (9%)	0	0
Cognitive disturbance	5 (11%)	6 (13%)	2 (4%)	0
Fatigue	4 (9%)	2 (4%)	2 (4%)	0
Vomiting	5 (11%)	3 (7%)	0	0
Dermatitis radiation	1 (2%)	0	0	0
Hearing impairment	4 (9%)	3 (7%)	0	0
Seizure	3 (7%)	0	1 (2%)	0
Increased alanine aminotransferase	3 (7%)	1 (2%)	0	0
Anaemia	1 (2%)	0	0	0
Hyponatraemia	1 (2%)	0	0	0
Hypotension	2 (4%)	0	0	0
Meningitis	0	0	0	0
Depression	2 (4%)	0	0	0
Thrombocytopenia	0	0	0	0
Neutropenia	4 (9%)	0	0	0
Headache	2 (4%)	1 (2%)	0	0
Intracranial haemorrhage	0	0	0	0
Central nervous system necrosis	0	0	0	0

A total of 46 cases of patients were evaluated.