Research Article
Fractionated Stereotactic Radiation Therapy Using Volumetric Modulated Arc Therapy in Patients with Solitary Brain Metastases
Table 4
Adverse event stratification according to the fraction dose.
| | Adverse events | , | , | value | | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| | Nausea | 1 | 1 | 0 | 0 | 4 | 3 | 0 | 0 | 0.215 | | Cognitive disturbance | 2 | 2 | 1 | 0 | 3 | 4 | 1 | 0 | >0.999 | | Fatigue | 1 | 0 | 1 | 0 | 3 | 2 | 1 | 0 | >0.999 | | Vomiting | 1 | 1 | 0 | 0 | 4 | 2 | 0 | 0 | >0.999 | | Dermatitis radiation | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | - | | Hearing impairment | 1 | 1 | 0 | 0 | 3 | 2 | 0 | 0 | >0.999 | | Seizure | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | - | | Increased alanine aminotransferase | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | - | | Anaemia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | - | | Hyponatraemia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | - | | Hypotension | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | - | | Meningitis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | | Depression | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | - | | Thrombocytopenia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | | Neutropenia | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | - | | Headache | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | - | | Intracranial haemorrhage | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | | Central nervous system necrosis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
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A total of 46 cases of patients were evaluated. Nonparametric rank sum test was used for 2 group comparisons, where “-” represents noncomparable.
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