3D Culture System for Liver Tissue Mimicking Hepatic Plates for Improvement of Human Hepatocyte (C3A) Function and Polarity

Figure 4

Dynamic testing of hepatocyte function: comparison of CYP1A2 synthesis (a), CYP2A6 synthesis (b), CYP3A4 synthesis (c), glutathione-S-transferase (GST) synthesis (d), diazepam (DIA) synthesis (e); ammonia (NH₃) metabolism (f); urea synthesis (g), testosterone (TT) metabolism (h), and pregnane X receptor (PXR) synthesis (i), albumin (ALB) synthesis (j), α1-antitrypsin (AAT) synthesis (k), apolipoprotein A1 (APOA1) synthesis (l), transferrin (TF) synthesis (m), glucokinase (GCK) synthesis (n), Factor II (F2) synthesis (o), Factor V (F5) synthesis (P), and Factor VII (F7) synthesis (q). Comparison of the data are presented as . Two-way ANOVA: H vs. P: , , ; H vs. S: ^▲, ^▲▲, ^▲▲▲; H vs. M: ^■, ^■■, ^■■■. H: hepatic plate-mimetic group; M: mixed 3D group; S: sandwich group; P: mixed 2D/plate group.

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