3D Culture System for Liver Tissue Mimicking Hepatic Plates for Improvement of Human Hepatocyte (C3A) Function and Polarity

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Liver function category</td><td class="align_center">Marker</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Detoxification</td><td class="align_center">CYP3A4, CYP2D6, CYP1A2, DIA, GST</td></tr><tr><td class="align_left">Ammonia metabolism and urea synthesis</td><td class="align_center">NH<sub>3</sub>, urea</td></tr><tr><td class="align_left">Glucose metabolism</td><td class="align_center">GCK</td></tr><tr><td class="align_left">Protein metabolism</td><td class="align_center">ALB, TF, AAT, APOA1</td></tr><tr><td class="align_left">Hormone metabolism</td><td class="align_center">PXR/NR1I2, TT</td></tr><tr><td class="align_left">Synthesis of coagulation factors</td><td class="align_center">F2, F5, F7</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>DIA: diazepam; GST: glutathione-S-transferase; NH<sub>3</sub>: ammonia; GCK: glucokinase; ALB: albumin; TF: transferrin; AAT: <i>α</i>1-antitrypsin; APOA1: apolipoprotein A1; PXR/NR1I2: pregnane X receptor; F2: coagulation factor II; F5: coagulation factor V; F7: coagulation factor VII.<br/></div></td></tr></table>

<div>Table of liver function categories.</div>

BioMed Research International

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Table 2

Table 2: 3D Culture System for Liver Tissue Mimicking Hepatic Plates for Improvement of Human Hepatocyte (C3A) Function and Polarity 