Research Article
Prognostic Evaluation for Patients over 45 Years Old with Gallbladder Adenocarcinoma Resection: A SEER-Based Nomogram Analysis
Table 2
Univariate and multivariate Cox regression analyses of OS for patients with gallbladder adenocarcinoma in the training cohort.
| Characteristics | Variable level | Univariate analysis | Multivariate analysis | HR | 95% CI | value | HR | 95% CI | value |
| Age (years) | | | | <0.001 | | | <0.001 | ≤65 | Reference | | | Reference | | | >65 | 1.55 | 1.317-1.824 | <0.001 | 1.686 | 1.400-1.988 | <0.001 | Marital status | | | | 0.016 | | | 0.001 | Married | Reference | | | Reference | | | Unmarried | 1.2 | 1.035-1.39 | 0.016 | 1.298 | 1.117-1.508 | 0.001 | Race | | | | 0.003 | | | 0.11 | White | Reference | | | | | | Black | 0.757 | 0.591-0.971 | 0.028 | | | 0.47 | Other | 0.712 | 0.559-0.906 | 0.006 | | | 0.062 | Sex | | | | 0.516 | | | | Male | Reference | | | | | NI | Female | | | 0.516 | | | | Grade | | | | <0.001 | | | 0.06 | I | Reference | | | Reference | | | II | 1.385 | 1.071-1.79 | 0.013 | 1.234 | 0.952-1.600 | 0.112 | III | 1.947 | 1.503-2.523 | <0.001 | 1.237 | 0.947-1.615 | 0.119 | IV | 4.396 | 2.474-7.81 | <0.001 | 2.295 | 1.282-4.109 | 0.005 | T stage | | | | <0.001 | | | <0.001 | T1 | Reference | | | Reference | | | T2 | 1.565 | 1.112-2.202 | 0.01 | 1.229 | 0.868-1.741 | 0.245 | T3 | 3.639 | 2.59-5.114 | <0.001 | 2.424 | 1.699-3.459 | <0.001 | T4 | 6.902 | 4.287-11.112 | <0.001 | 3.715 | 2.262-6.101 | <0.001 | LODDS | | | | <0.001 | | | <0.001 | LODDS1 | Reference | | | Reference | | | LODDS2 | 1.525 | 1.262-1.842 | <0.001 | 1.316 | 1.087-1.593 | 0.005 | LODDS3 | 3.228 | 2.659-3.919 | <0.001 | 2.515 | 2.053-3.080 | <0.001 | M stage | | | | <0.001 | | | | M0 | Reference | | | Reference | | | M1 | 3.04 | 2.531-3.651 | <0.001 | 2.067 | 1.704-2.508 | <0.001 | LN surgery scope | | | | 0.003 | | | | None | Reference | | | | | NI | 1~3 | 1.462 | 0.825-2.593 | 0.193 | | | | ≥4 | 1.12 | 0.625-2.005 | 0.704 | | | | Radiation | | | | 0.289 | | | | Yes | Reference | | | | | NI | No/unknown | 1.217 | 0.991-1.493 | 0.289 | | | | Chemotherapy | | | | 0.512 | | | | Yes | Reference | | | | | NI | No/unknown | 1.084 | 0.925-1.271 | 0.512 | | | | Tumor size (cm) | | | | <0.001 | | | 0.003 | <1.9 | Reference | | | Reference | | | 1.9~4.8 | 1.605 | 1.31-1.965 | <0.001 | 1.176 | 0.952-1.453 | 0.132 | ≥4.8 | 2.611 | 2.084-3.271 | <0.001 | 1.503 | 1.179-1.916 | 0.001 |
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AJCC: American Joint Committee on Cancer; LODDS: log of positive lymph nodes. Level of significance: ; ; . |