Acidic Compartment Size, Positioning, and Function during Myogenesis and Their Modulation by the Wnt/Beta-Catenin Pathway

Figure 5

Acidic compartment positioning changes during the differentiation of chick myogenic cells and after disturbances in lysosomal function. Chick muscle cells were treated with DMSO, Lys05, BIO, and Wnt3a or transfected with siRNA to LAMP-2 or eGFP. Live cells were labeled with acridine orange, and the distance between acidic compartments (AC) and the nuclei of the cells was quantified (a–d).

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