Antiaging Properties of Exosomes from Adipose-Derived Mesenchymal Stem Cells in Photoaged Rat Skin

Figure 3

Skin changes of SD rats after treatment with ADSC-derived exosomes. (a) HE staining showed the changes in epidermal and dermal thickness of SD rats exposed to UVB 28 d after ADSC-derived exosome treatment (×100). Ki67 immunostaining showed the proliferation of basal cells of SD rats exposed to UVB and those treated with ADSC-derived exosomes for 28 days (×100). (b) The thickness of the epidermis in the ADSC-derived exosome treatment group was less than that in the control group at 7 days, 14 days, and 28 days after treatment (), indicating that the ADSC-derived exosome treatment reduced the epidermal layer thickness of photoaged skin. (c) The thickness of the dermis in the ADSC-derived exosome treatment group was higher than that in the control group at 7 days, 14 days, and 28 days after treatment (), indicating that the ADSC-derived exosome treatment increased the dermal layer thickness of photoaged skin.

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