miR-425-5p Acts as a Molecular Marker and Promoted Proliferation, Migration by Targeting RNF11 in Hepatocellular Carcinoma

Table 2

Univariate and multivariate analysis of different prognostic variables influencing RFS in HCC patients.

Variables		Univariate analysis		Multivariate analysis model
		HR (95% CI)		HR (95% CI)
Gender		0.348 (0.475-2.047)	0.640
Male	60
Female	45
Age (year)		0.547 (0.308-1.571)	0.834
<50	48
≥50	57
Tumor size (cm)		1.184 (0.674-1.876)	0.374
≤5	50
>5	55
AFP(ng/ml)		1.037 (0.408-1.573)	0.941
≤20	38
>20	67
HBsAg		0.768 (1.270-3.317)	0.329
Positive	65
Negative	40
TNM stage		1.204 (1.743-3.269)	0.009	1.334 (1.278-3.004)	0.017
I/II	47
III/IV	58
Multiplicity		1.427 (1.127-3.690)	0.022	1.409 (1.045-3.347)	0.024
Single	42
Multiple (≥2)	63
Vascular invasion		1.894 (1.806-5.974)	0.014	1.743 (1.874-4.339)	0.010
Presence	55
Absence	50
Liver cirrhosis		0.884 (0.474-1.634)	0.735
Presence	57
Absence	48
Intrahepatic metastasis		0.986 (0.640-2.047)	0.033	1.228 (1.475-3.993)	0.028
Presence	52
Absence	53
miR-425-5p expression		1.220 (0.471-1.649)	0.017	1.171 (0.503-1.843)	0.011
High	73
Low	32

HR: hazard rate; CI: confidence interval.