miR-425-5p Acts as a Molecular Marker and Promoted Proliferation, Migration by Targeting RNF11 in Hepatocellular Carcinoma

Table 3

Univariate and multivariate analysis of different prognostic variables influencing DSS in HCC patients.

Variables		Univariate analysis		Multivariate analysis model
		HR (95% CI)		HR (95% CI)
Gender		0.535 (0.137-1.087)	0.370
Male	60
Female	45
Age (year)		0.472 (0.634-1.871)	0.476
<50	48
≥50	57
Tumor size (cm)		0.807 (0.934-1.997)	0.710
≤5	50
>5	55
AFP (ng/ml)		1.343 (0.841-1.947)	0.841
≤20	38
>20	67
HBsAg		1.005 (0.475-2.614)	0.934
Positive	65
Negative	40
TNM stage		1.374 (1.057-3.004)	0.019	1.201 (1.847-4.647)	0.011
I/II	47
III/IV	58
Multiplicity		1.340 (0.543-1.670)	0.012	1.284 (0.843-1.842)	0.015
Single	42
Multiple (≥2)	63
Vascular invasion		1.556 (1.706-2.648)	0.030	1.408 (1.641-2.330)	0.025
Presence	55
Absence	50
Liver cirrhosis		1.109 (0.847-1.739)	0.535
Presence	57
Absence	48
Intrahepatic metastasis		0.884 (1.045-2.984)	0.043	1.047 (2.034-5.376)	0.038
Presence	52
Absence	53
miR-425-5p expression		1.469 (0.567-1.886)	0.007	1.338 (0.807-2.364)	0.010
High	73
Low	32

HR: hazard rate; CI: confidence interval.