Research Article
Toll-like-Receptor Gene Polymorphisms in Tunisian Endemic Pemphigus Foliaceus
Table 2
Genotype and allele frequencies of TLR3, 4 and 7 studied SNPs in Pemphigus foliaceus patient’s groups and their relative matched healthy controls.
| | Group 1
♀ age of onset under 35 years | Group 2
♀♂ age of onset above 35 years | Group 3
Endemic localities | Group 4
Nonendemic localities | | Gene/SNP | Case
(%) | Controls
(%) |
OR, 95% CI | Case
(%) | Controls
(%) |
OR, 95% CI | Case
(%) | Controls
(%) |
OR, 95% CI | Case
(%) | Controls
(%) |
OR, 95% CI |
| | TLR3 > rs 5743305 | | | | | | | | | | | | | A | 27 (24.5) | 58 (34.9) | 0.067 | 30 (39.4) | 59 (26.8) | 0.038
1.78 [1.03-3] | 18 (24.3) | 50 (36.2) | 0.07 | 39 (34.8) | 67 (27) | 0.13 | | T | 83 (75.4) | 108 (65) | | 46 (60.5) | 161 (73.1) | | 56 (75.6) | 88 (63.7) | | 73 (65.1) | 181 (72.9) | | | AA | 7 (12.7) | 17 (20.4) | 0.23 | 8 (21) | 7 (6.3) | 0.009
3.92 [1.3-11.7] | 4 (10.8) | 12 (17.3) | 0.36 | 11 (19.6) | 12 (9.6) | 0.063 | | AT | 13 (23.6) | 24 (28.9) | 0.4 | 14 (36.8) | 45 (40.9) | 0.6 | 10 (27) | 26 (37.6) | 0.26 | 17 (30.3) | 43 (34.6) | 0.5 | | TT | 35 (63.6) | 42 (50.6) | 0.1 | 16 (42.1) | 58 (52.7) | 0.2 | 23 (62.1) | 31 (44.9) | 0.09 | 28 (50) | 69 (55.6) | 0.4 | | TLR3 > rs3775294 | | | | | | | | | | | | | | C | 36 (37) | 57 (36.5) | 0.9 | 29 (32.5) | 108 (51.9) | 0.03
0.57 [0.3-0.9] | 31 (50) | 58 (44.6) | 0.4 | 34 (26.4) | 107 (45.7) | 0.006
0.52 [0.32-0.83] | | T | 62 (63) | 99 (63.4) | | 47 (67.5) | 100 (48) | | 31 (50) | 72 (55.3) | | 78 (73.5) | 127 (54.2) | | | CC | 7 (13) | 14 (17.9) | 0.5 | 6 (16) | 32 (30.7) | 0.07 | 9 (29) | 18 (27.6) | 0.8 | 4 (7.2) | 28 (23.9) | 0.007
0.24 [0.08-0.74] | | CT | 22 (45) | 29 (37.1) | 0.4 | 17 (45) | 44 (42.3) | 0.1 | 13 (42) | 22 (33.8) | 0.7 | 26 (46.4) | 51 (43.5) | 0.7 | | TT | 20 (42) | 35 (44.8) | 0.6 | 15 (39) | 28 (26.9) | 0.1 | 9 (29) | 18 (27.6) | 0.8 | 26 (46.4) | 38 (32.4) | 0.07 | | TLR3 > rs3775291 | | | | | | | | | | | | | | A | 12 (11) | 12 (7.4) | 0.29 | 9 (12.5) | 26 (12.2) | 0.95 | 8 (10.5) | 10 (7.4) | 0.44 | 13 (12.5) | 28 (11.6) | 0.85 | | G | 96 (89) | 150 (92.5) | | 63 (87.5) | 186 (87.7) | | 68 (89.4) | 124 (92.5) | | 91 (87.5) | 212 (88.3) | | | AA | 0 | 1 (1.2) | | 0 | 0 | — | 0 | 0 | — | 0 | 1 (0.8) | 0.78 | | AG | 12 (22.2) | 10 (12.3) | 0.1 | 9 (25) | 26 (24.5) | 0.9 | 8 (21) | 10 (14.9) | 0.4 | 13 (25) | 26 (21.6) | 0.63 | | GG | 42 (77.7) | 70 (86.4) | 0.1 | 27 (74.9) | 80 (75.4) | 0.9 | 30 (78.9) | 57 (85) | 0.4 | 39 (74.9) | 93 (77.5) | 0.7 | | TLR4 > rs4986790 | | | | | | | | | | | | | | A | 98 (94.2) | 148 (91.3) | 0.38 | 73 (96) | 201 (95.7) | 0.89 | 70 (94.5) | 124 (92.5) | 0.57 | 101 (95.2) | 225 (94.5) | 0.77 | | G | 6 (5.7) | 14 (8.6) | | 3 (3.9) | 9 (4.2) | | 4 (5.4) | 10 (7.4) | | 5 (4.7) | 13 (5.4) | | | AA | 46 (88.4) | 68 (83.9) | 0.6 | 35 (92.1) | 97 (92.3) | 0.79 | 33 (89.1) | 58 (86.5) | 0.69 | 48 (90.5) | 107 (89.9) | 0.9 | | AG | 6 (11.5) | 12 (14.8) | | 3 (7.8) | 7 (6.6) | | 4 (10.8) | 8 (11.9) | 0.86 | 5 (9.4) | 11 (9.2) | 0.9 | | GG | 0 | 1 (1.2) | | 0 | 1 (0.9) | | 0 | 1 (1.4) | 0.45 | 0 | 1 (0.8) | 0.13 | | TLR4 > rs4986791 | | | | | | | | | | | | | | C | 99 (95.1) | 109 (95.6) | 0.8 | 74 (97.3) | 190 (97.9) | 0.77 | 71 (95.9) | 85 (94.4) | 0.72 | 102 (96.2) | 214 (98.1) | 0.44 | | T | 5 (4.8) | 5 (4.3) | | 2 (2.6) | 4 (2) | | 3 (4.1) | 5 (5.6) | | 4 (3.7) | 4 (1.8) | | | CC | 47 (90.3) | 52 (91.2) | 0.87 | 36 (94.7) | 93 (95.8) | 0.67 | 34 (91.8) | 40 (88.8) | 0.65 | 49 (92.4) | 105 (96.3) | 0.28 | | CT | 5 (9.6) | 5 (8.7) | 0.87 | 2 (5.2) | 4 (4.1) | 0.67 | 3 (8.1) | 5 (11.1) | 0.65 | 4 (7.5) | 4 (3.6) | 0.28 | | TT | 0 | 0 | — | 0 | 0 | — | 0 | 0 | — | 0 | 0 | — | | TLR7 > rs3853839 | | | | | | | | | | | | | | Female | | | | | | | | | | | | | | C | 57 (53.7) | 85 (57.3) | 0.56 | 45 (62.4) | 124 (64.2) | 0.79 | 42 (56.7) | 71 (57.2) | 0.94 | 60 (57.6) | 138 (63.5) | 0.28 | | G | 49 (46.2) | 62 (41.8) | | 27 (37.4) | 69 (35.7) | | 32 (43.2) | 53 (42.7) | | 44 (42.3) | 78 (35.9) | | | CC | 18 (33.9) | 22 (29.7) | 0.33 | 13 (36.1) | 33 (34.1) | 0.81 | 13 (35.1) | 19 (30.6) | 0.64 | 18 (34.6) | 36 (33.1) | 0.9 | | CG | 21 (39.6) | 38 (51.3) | 0.1 | 16 (44.4) | 47 (48.7) | 0.67 | 16 (43.2) | 33 (53.2) | 0.33 | 21 (40.3) | 52 (47.9) | 0.26 | | GG | 14 (26.4) | 12 (16.2) | 0.18 | 4 (11.1) | 9 (9.3) | 0.7 | 8 (21.6) | 10 (16.1) | 0.78 | 10 (19.2) | 11 (10.1) | 0.12 | | Male | | | | | | | | | | | | | | C | — | — | | 3 (50) | 14 (67) | 0.4 | | | | 3 (50) | 14 (67) | 0.4 | | G | — | — | | 3 (50) | 7 (33) | | | | | 3 (50) | 7 (33) | |
|
|
This case control-study enrolled 93 PF patients matched to 193 healthy control, whereas in some subjects the genotyping was failed.
|
