Research Article
Toll-like-Receptor Gene Polymorphisms in Tunisian Endemic Pemphigus Foliaceus
Table 3
Genotype and allele frequencies of TLR2 GT repeat inPemphigus foliaceus patient’s groups and their relative matched healthy controls.
| | Group 1
♀ age of onset under 35 years | Group 2
♀♂ age of onset above 35 years | Group 3
Endemic localities | Group 4
Nonendemic localities | Case
(%) | Controls
(%) |
OR, 95% CI | Case
(%) | Controls
(%) |
OR, 95% CI | Case
(%) | Controls
(%) |
OR, 95% CI | Case
(%) | Controls
(%) |
OR, 95%CI |
| | TLR2>(GT)n | | | | | | | | | | | | | | 12 | 2 (1.9) | 4 (4.9) | 0.2 | 2 (3.4) | 3 (1.8) | 0.5 | 1 (1.4) | 5 (6) | 0.1 | 3 (3.2) | 1 (0.6) | 0.1 | | 13 | 7 (6.7) | 4 (4.9) | 0.6 | 5 (8.6) | 5 (3.1) | 0.09 | 6 (8.5) | 3 (3.6) | 0.2 | 6 (6.5) | 6 (3.8) | 0.3 | | 14 | 0 | 1 (1.2) | — | 0 | 1 (0.6) | — | 0 | 1 (1.2) | — | 0 | 1 (0.6) | 0.4 | | 15 | 0 | 0 | — | 0 | 1 (0.6) | — | 0 | 0 | — | 0 | 1 (0.6) | 0.4 | | 16 | 1 (0.9) | 1 (1.2) | 0.8 | 0 | 5 (3.1) | — | 1 (1.4) | 4 (4.8) | 0.2 | 0 | 2 (1.2) | 0.27 | | 17 | 3 (2.8) | 4 (4.9) | 0.45 | 5 (8.6) | 10 (6.3) | 0.5 | 1 (1.4) | 5 (6) | 0.1 | 7 (7.6) | 9 (5.8) | 0.58 | | 18 | 28 (26.9) | 16 (19.9) | 0.27 | 13 (22.4) | 28 (17.7) | 0.4 | 24 (34.2) | 15 (18.2) | 0.02
2.3 [1.1-4.9] | 17 (18.4) | 29 (18.8) | 0.9 | | 19 | 25 (24) | 21 (26..2) | 0.7 | 14 (24.1) | 30 (18.9) | 0.4 | 21 (30) | 14 (17) | 0.059 | 18 (19.5) | 37 (24) | 0.5 | | 20 | 12 (11.5) | 10 (12.4) | 0.8 | 7 (12) | 16 (10.5) | 0.6 | 8 (11.4) | 5 (6) | 0.2 | 11 (11.9) | 21 (13.6) | 0.7 | | 21 | 8 (7.6) | 3 (3.7) | 0.26 | 1 (1.7) | 17 (10.7) | 0.03 | 4 (5.7) | 12 (14.6) | 0.07 | 5 (5.4) | 8 (5.1) | 0.9 | | 22 | 4 (3.8) | 4 (4.9) | 0.7 | 2 (3.4) | 9 (5.6) | 0.5 | 1 (1.4) | 3 (3.6) | 0.4 | 5 (5.4) | 10 (6.4) | 0.7 | | 23 | 11 (10.5) | 11 (13.7) | 0.5 | 6 (10.3) | 22 (13.9) | 0.48 | 3 (4.2) | 13 (15.8) | 0.02
0.2 [0.06-0.87] | 14 (15.2) | 19 (12.3) | 0.5 | | 24 | 1 (0.9) | 0 | — | 2 (3.4) | 4 (2.5) | 0.7 | 0 | 1 (1.2) | — | 3 (3.2) | 3 (1.9) | 0.5 | | 25 | 1 (0.9) | 1 (1.2) | 0.8 | 1 (1.7) | 5 (3.1) | 0.56 | 0 | 1 (1.2) | — | 2 (2.1) | 5 (3.2) | 0.6 | | 26 | 1 (0.9) | 0 | — | 0 | 2 (1.2) | 0.38 | 0 | 0 | — | 1 (1) | 2 (1.2) | 0.7 | | GT18/GT19 | 12 (23) | 2 (4.9) | 0.16 | 6 (20.6) | 6 (7.5) | 0.054 | 12 (34.2) | 1 (2.4) | 2.3 10-4
20 [2.5-171] | 6 (13) | 7 (11) | 0.5 | | GT18/GT20 | 5 (9.6) | 0 | 0.043 | 3 (10.3) | 2 (2.5) | 0.08 | | | | 5 (10.8) | 1 (1.2) | 0.017 | | 77 | 54 | 0.47 | 37 | 100 | 0.9 | 58 | 49 | 0.0018
3.26 [1.5-7] | 56 | 105 | 0.052 |
| 27 | 25 | | 21 | 58 | | 12 | 33 | | 36 | 49 | |
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This case control-study enrolled 93 PF patients matched to 193 healthy control, whereas in some subjects the genotyping was failed.
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