Altered Gut Microbiota and Shift in Bacteroidetes between Young Obese and Normal-Weight Korean Children: A Cross-Sectional Observational Study

Figure 1

Gut microbiota composition in the normal-weight (a) and obese (b) groups. The inner circle shows the composition at the phylum level, and the outer circle shows the composition at the family level. Violin plot showing the median, spread, and distribution pattern of the relative abundance of Bacteroidetes between the obese group and the normal-weight group (c). Correlation scatter plot of the relative abundance (%) of Bacteroidetes and BMI -scores of participants (d). Receiver operator characteristic (ROC) curve of the relative abundance of Bacteroidetes to predict obesity (e). The area under the curve (AUC) was 0.74 (95% CI: 0.60-0.89). Interaction between Bacteroidetes and BMI -score (F). Cluster analysis was performed with NMDS analysis using Bray-Curtis distance (g). Principal coordinate analysis of the gut microbiota at the genus level according to the normal-weight (red) and obese (blue) groups (h). Principal components (PCs) 1, 2, and 3 explained 36.379%, 10.656%, and 9.43% of the variance, respectively (h). This result suggests that the gut microbial composition observed in the obese group was significantly different from that of the normal-weight group (, PERMANOVA on Fast UniFrac distances).