Research Article

Adverse Drug Reaction due to Antidepressants among Patients with Depression in a Private Psychiatric Hospital of Nepal

Table 2

Summary of adverse drug reactions based on severity, preventability, management, and outcome.

CharacteristicsCategoryn (%)

Causality (Naranjo’s algorithm scale)Definite0 (0.00)
Probable30 (55.55)
Possible24 (44.44)
Doubtful0 (0.00)
Severity (modified Hartwig and Siegel scale)Mild (1-2 points),13 (24.07)
Moderate (3-4 points)36 (66.66)
Severe (5-7 points)5 (9.25)
Preventability (modified Schumock and Thornton scale)Definitely preventable18 (33.33)
Probably preventable24 (44.44)
Not preventable12 (22.22)
ManagementStopped the medication19 (35.18)
Substituted another drug19 (35.18)
Reduced the dose9 (16.66)
Added another drug7 (12.96)
Outcome of managementRecovered36 (66.66)
Recovering18 (33.33)
Fatal0 (0.00)