The Potential Diagnostic Value of Exosomal Long Noncoding RNAs in Solid Tumors: A Meta-Analysis and Systematic Review

Table 1

Characteristics of the included studies.

Author	Year	Country	Ethnic	Cancer type	lncRNA	Sample	Case	Control	TP	FP	FN	TN	Sensitivity (%)	Specificity (%)	QUADAS score
Qier L	2014	China	Asian	GC	LINC00152	Plasma	79	81	38	12	41	69	0.481	0.852	4
Jiangting Wang	2014	China	Asian	LSCC	HOTAIR	Serum	52	49	49	13	3	36	0.942	0.735	4
Tong Liu	2016	China	Asian	CC	CRNDE-h	Serum	148	160	104	15	44	145	0.703	0.904	4
Xianxiu Ge	2017	China	Asian	CGC	ENST00000588480.1	Serum	35	56	22	15	13	41	0.629	0.732	3
Rui Zhang	2017	China	Asian	NSCLC	MALAT-1	Serum	77	33	46	6	31	27	0.601	0.809	3
Mei Xue	2017	China	Asian	BD	UCA1	Serum	30	30	24	5	6	25	0.800	0.833	4
Huaying Dong	2018	China	Asian	BC	SNHG14	Serum	72	72	58	20	14	52	0.800	0.725	4
Min Kang	2018	China	Asian	ESCC	PART1	Serum	79	79	62	11	17	68	0.786	0.865	2
Li Sun	2018	China	Asian	HCC	LINC00161	Serum	56	56	42	15	14	41	0.750	0.732	5
Jiansong Wang	2018	China	Asian	BC	H19	Serum	52	52	39	11	13	41	0.741	0.781	6
Hong Xu	2018	China	Asian	HCC	ENSG00000258332.1	Serum	60	60	43	10	17	50	0.716	0.834	3
Fatemeh Yazarlou	2018	Iran	Asian	BD	UCa1-201	Urine	59	24	44	4	15	20	0.754	0.812	4
Fatemeh Yazarlou	2018	Iran	Asian	BD	UCa1-203	Urine	59	24	43	6	16	18	0.724	0.750	4
Fatemeh Yazarlou	2018	Iran	Asian	BD	MalaT1	Urine	59	24	38	4	21	20	0.638	0.833	4
Fatemeh Yazarlou	2018	Iran	Asian	BD	LinC00355	Urine	59	24	40	5	19	19	0.680	0.792	4
Yao Zhan	2018	China	Asian	BD	MALAT1	Urine	104	104	75	16	29	88	0.721	0.846	4
Yao Zhan	2018	China	Asian	BD	PCAT-1	Urine	104	104	75	19	29	85	0.721	0.817	4
Yao Zhan	2018	China	Asian	BD	SPRY4-IT1	Urine	104	104	69	24	35	80	0.663	0.769	4
Yao Zhan	2018	China	Asian	BD	MALAT1	Urine	80	80	63	26	17	54	0.787	0.675	4
Yao Zhan	2018	China	Asian	BD	PCAT-1	Urine	80	80	57	16	23	64	0.712	0.800	4
Yao Zhan	2018	China	Asian	BD	SPRY4-IT1	Urine	80	80	70	28	10	52	0.875	0.650	4
Wei Zhang	2018	China	Asian	NSCLC	RP11-838N2.4	Serum	78	78	58	26	20	52	0.745	0.673	3
Rui Zhao	2018	China	Asian	GC	HOTTIP	Serum	126	120	88	18	38	102	0.698	0.85	3
Rui Zheng	2018	China	Asian	BD	PTENP1	Plasma	50	60	33	9	17	51	0.654	0.842	3
Yu-Hui Wang	2018	China	Asian	PSA	SAP30L-AS1	Plasma	34	30	21	5	13	25	0.611	0.821	5
Yu-Hui Wang	2018	China	Asian	PSA	SChLAP1	Plasma	33	30	29	7	4	23	0.879	0.767	5
Yun Teng	2019	China	Asian	LSCC	SOX2-OT	Plasma	75	79	57	21	18	58	0.760	0.732	6
Shujun Zhang	2019	China	Asian	BD	PCAT-1, UBC1, SNHG16	Serum	160	160	128	40	32	120	0.800	0.750	2

GC: gastric cancer; LSCC: laryngeal squamous cell carcinoma; CC: colorectal cancer; CGC: cholangiocarcinoma; NSCLC: nonsmall cell lung cancer; BD: bladder tumor; BC: breast cancer; ESCC: esophageal squamous cell carcinoma; HCC: hepatocellular carcinoma; PSA: prostate cancer; TP: true positivity; FP: false positivity; TN: true negativity; FN: false negativity.