The Potential Diagnostic Value of Exosomal Long Noncoding RNAs in Solid Tumors: A Meta-Analysis and Systematic Review

Table 4

Summary results of subgroup for liquid exosomes in the diagnosis of cancer.

Subgroup	Number of studies	Sensitivity (95% CI)	Specificity (95% CI)	DLR+ (95% CI)	DLR- (95% CI)	DOR (95% CI)	AUC (95% CI)
Type of cancer
Digestive system tumor	8	0.73 (0.63-0.81)	0.83 (0.78-0.87)	4.21 (3.28-5.41)	0.33 (0.24-0.45)	12.87 (8.12-20.41)	0.86 (0.82-0.89)
Urinary system tumor	15	0.74 (0.70-0.78)	0.79 (0.75-0.82)	3.4 (3.0-4.0)	0.33 (0.29-0.38)	10 (8-13)	0.83 (0.80-0.86)
Type of specimen
Blood	18	0.74 (0.69-0.78)	0.80 (0.76-0.83)	3.7 (3.1-4.3)	0.33 (0.28-0.39)	11 (9-14)	0.84 (0.81-0.87)
Urine	10	0.73 (0.69-0.78)	0.78 (0.73-0.82)	3.3 (2.7-4.0)	0.34 (0.30-0.40)	10 (7-12)	0.82 (0.78-0.85)
Sample size
>70	15	0.73 (0.69-0.77)	0.79 (0.75-0.83)	3.5 (3.0-4.2)	0.34 (0.29-0.39)	10 (8-13)	0.83 (0.79-0.86)
<70	13	0.74 (0.68-0.79)	0.79 (0.75-0.83)	3.5 (3.0-4.2)	0.33 (0.27-0.40)	11 (8-15)	0.83 (0.79-0.86)

DLR: degrees of freedom; DOR: diagnostic OR; AUC: area under the curve.