Disease-Associated Circular RNAs: From Biology to Computational Identification

Figure 2

Biogenesis of circRNAs. Pre-mRNAs go through two splicing pathways to generate a linear RNA via highly efficient canonical splicing (top) or to produce circRNAs and an alternatively spliced linear RNA via poorly efficient backsplicing. As a result, different types of circRNAs can be produced (see discussion in text). Illustration was generated using BioRender.