Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection

Table 2

Univariate analysis and Cox proportional hazards regression analysis of HBsAg seroclearance in chronic hepatitis B patients.

Variable	Univariate analysis				Multivariate analysis
		Exp(B)	95% CI			Exp(B)	95% CI
			LO	UP			LO	UP
Gender (male)	0.811	0.912	0.427	1.948
Age (year)
<40		Reference
≥40; <60	0.853	1.209	0.163	8.992
≥60	0.712	1.468	0.192	11.224
BMI (kg/m^2)	0.016	1.123	1.022	1.234	0.001	1.170	1.064	1.229
History of alcohol intake	0.050	2.292	1.001	5.251
Family history of HBV	0.356	0.732	0.377	1.421
Family history of HCC	0.744	1.190	0.420	3.372
HCC
HCC on inclusion	0.811	20.673	0.000	1.318E+12
New-onset HCC	0.999	0.999	0.000	9.934E+11
AST (U/l)
≥15; <40		Reference
≥40	0.027	2.555	1.112	5.870
ALT (U/l)
≥3; <35		Reference
≥35	0.004	3.062	1.434	6.539
Albumin (g/l)	0.114	1.083	0.981	1.196
Total bilirubin (μmol/l)	0.448	1.003	0.996	1.010
HBV DNA log10 (IU/ml)
<2		Reference
≥2; <4	0.005	17.720	2.391	131.323
≥4; < 7	0.047	8.342	1.026	67.851
>7	0.424	2.447	0.273	21.908
qHBsAg log10 (IU/ml)
≤1		Reference				Reference
>1; ≤2	<0.001	130.255	57.677	294.161	<0.001	106.778	43.537	261.883
>2; ≤3	<0.001	11.476	3.965	33.213	0.001	5.945	1.993	17.736
>3	0.135	2.395	0.762	7.533	0.139	2.382	0.755	7.517
HBeAg status	<0.001	11.042	3.381	36.066	0.016	4.644	1.336	16.138
Antiviral treatment	0.032	0.480	0.245	0.939

Abbreviations: CHB: chronic hepatitis B; BMI: body mass index; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; ALT: alanine aminotransferase; AST: aspartate aminotransferase; HBV DNA: hepatitis B viral deoxyribonucleic acid load at baseline; qHBsAg: quantitative hepatitis B surface antigen; HBeAg: hepatitis B e-antigen.