Evaluation of Loopamp Assay for the Diagnosis of Pulmonary Tuberculosis in Cambodia

Table 2

Sensitivity and specificity of LED-fluorescent microscopy, TB-LAMP, and Xpert MTB/RIF.

Test	Culture result		Sensitivity among culture-positive MTB			Specificity; %; (95% CI)
	MTB-positive; () positive/negative	MTB-negative; () positive/negative	Smear-positive; %; (95% CI)	Smear-negative; %; (95% CI)	Overall; %; (95% CI)
Smear microscopy center
Microscopy	109/48	6/336	—	—	69.4; (62.2-76.6)	98.2; (96.8-99.6)
TB-LAMP	128/29	9/333	94.5; (90.2-98.8)	52.1; (38.0-66.2)	81.5; (74.5-87.6)	97.4; (95.7-99.1)
Xpert	150/7	11/331	99.1; (93.6-99.9)	87.5; (74.2-94.4)	95.5; (92.3-98.8)	96.8; (94.9-98.7)
Central laboratory
TB-LAMP	90/7	4/95	100	56.3; (29.8-79.6)	92.8; (87.6-97.9)	96.0; (92.1-99.8)
Xpert	88/9	3/96	100	43.8; (20.4-70.2)	90.7; (85.0-96.5)	97.0; (93.6-1.0)