A Novel Prediction Model for Significant Liver Fibrosis in Patients with Chronic Hepatitis B

Table 2

Univariate and Multivariate Analysis of Predictors of the training set.

Variable	Univariate		Multivariate
	OR (95% CI)		OR (95% CI)
Age (year)	1.020 (0.998-1.042)	0.077
Gender (male/female)	1.159 (0.664-2.024)	0.604
ALT (U/L)	1.002 (1.000-1.004)	0.025
AST (U/L)	1.005 (1.001-1.008)	0.007
PLT (×10^9/L)	0.993 (0.989-0.998)	0.005	0.993 (0.989-0.998)	0.008
HA (ng/mL)	1.015 (1.008-1.021)	<0.001
LN (ng/mL)	1.0332 (1.017-1.047)	<0.001	1.024 (1.008-1.041)	0.003
IVC (ng/mL)	1.011 (1.007-1.016)	<0.001
PIIINP (ng/mL)	1.112 (1.071-1.154)	<0.001	1.095 (1.055-1.138)	<0.001
FIB4	1.533 (1.214-1.936)	<0.001
APRI	1.700 (1.246-2.322)	0.001

ALT: alanine aminotransferase; AST: aspartate aminotransferase; PLT: blood platelet; HA: hyalurona; LN: laminin; IVC: type IV collagen; PIIINP: procollagen type III N-terminal peptide; FIB-4: fibrosis 4 score; APRI, AST: platelet ratio index; OR: odds ratio; 95% CI: 95% confidence interval. Multivariate analysis was adjusted for age, ALT, AST, PLT, HA, LN, IVC, and PIIINP.