Review Article
Perspectives of the Application of Liquid Biopsy in Colorectal Cancer
Table 1
Application value of CTCs in CRC.
| | Reference | Biomarkers | Methods | Potential clinical utility |
| | [66] | CD45 | scrm PCR | Screening and early detection | | [76, 85, 87] | EpCAM | CellSearch™ | Prognostic | | [83] | CD45 | Cyttel | Predictive and prognostic | | [89] | CK-19, EpCAM | CK19-Epispot and CellSearch™ | Prognostic | | [103] | EpCAM, APC, KRAS, PIK3CA | NGS, CGH, CellSearch™ | Therapy and relapse monitoring | | [105] | KRAS | PNA-based qPCR | Therapy monitoring | | [114] | LGR5, EMT | CanPatrol™, mRNA ISH | Prognostic | | [115] | CK20 | CMx platform | Monitoring early recurrence | | [116, 117] | EpCAM | CellSearch™ | Predictive and prognostic |
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Abbreviations: scrm PCR: single-cell RNA and mutational analysis PCR; NGS: next-generation sequencing; CGH: array-comparative genomic hybridization; PNA-based qPCR: peptide nucleic acid-based real-time PCR; mRNA ISH: mRNA in situ hybridization.
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