MAGE-Targeted Gold Nanoparticles for Ultrasound Imaging-Guided Phototherapy in Melanoma

Figure 3

Photothermal conversion efficiency and heat shock protein (HSP) evaluation in vivo. (a) IR thermal images of B16 tumor-bearing mice of the four groups (NS+laser, Au-NP+laser, Au-PFH-NP+laser, and MAGE-Au-PFH-NP+laser groups) taken at different times. (b) Plot of temperature change of four groups (NS+laser, Au-NP+laser, Au-PFH-NP+laser, and MAGE-Au-PFH-NP+laser groups) in vivo. (c) Immunofluorescent staining of HSP70 of tumor tissues dissected from different groups on the 1st day post treatments. The scale bar is 50 μm. (d) Quantitative analysis of HSP expression from different groups on the 1st day post treatments. (The data is shown as , per group; .).

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