MAGE-Targeted Gold Nanoparticles for Ultrasound Imaging-Guided Phototherapy in Melanoma

Figure 4

Fluorescence imaging in vivo. (a) Fluorescence images of B16 tumor-bearing mice after intravenous injection of MAGE-Au-PFH-NPs and Au-PFH-NPs at 0, 1, 2, 24, 48, and 72 h ( per group). (b) Plot of fluorescence images of B16 tumor-bearing mice after intravenous injection of MAGE-Au-PFH-NPs and Au-PFH-NPs at 0, 1, 2, 24, 48, and 72 h. The dotted circle instruction for the tumor mass. (c) Targeting ability of MAGE-Au-PFH-NPs and MAGE-R-Au-PFH-NPs to B16 cells observed under CLSM; the left line was cell nuclei stained by DAPI, the middle line was NP stained by DiI, and the right line was the merged result of the two fluorescence images.

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