Prognostic Value of Asymmetric Dimethylarginine in Patients with Heart Failure: A Systematic Review and Meta-analysis

Table 1

Characteristics of included studies.

First author	Publication year	Patients	Sample size	Mean/median age (years)	ADMA assay	Variable type	Comparison	Mean follow-up (months)	Variables adjusted	Outcomes	NOS
Duckelmann, C.	2007	CHF	276	70	HPLC	Categorical	Highest tertile vs. lowest vs. <0.51 μmol/L	14.2	Age, sex, GFR, LVEF, systolic blood pressure, and BMI	Cardiac decompensation, MACE, or all-cause death	9/9
Duckelmann, C.	2008	Acute decompensated HF	118	73	HPLC	Categorical	Above median vs. below vs. <3051 pg/mL	10.7	None	MACE, or all-cause death	9/9
Tang, W. H.	2008	Stable but symptomatic HF	132	57.8	HPLC	Continuous	Per ADMA log-1 SD increment	33	Age, eGFR, and LVEF	Death, cardiac transplantation, or heart failure hospitalization	8/9
Anderssohn, M	2012	CHF due to ICM or DCM	341	55.1	HPLC	Continuous	Per ADMA log-1 unit increment	39.6	None	All-cause mortality	8/9
Hsu, C. P.	2012	CHF	285	70	HPLC	Continuous & categorical	Above vs. below the best discriminating ADMA level by ROC vs. <0.48 mmol/L	26.4	Age, log NT-proBNP level, eGFR and LVEF	Major adverse cardiovascular events (MACE) or cardiac decompensation needing hospitalization	9/9
Zairis, M. N.	2012	Acute decompensation CHF	651	73	HPLC	Categorical	Highest quartile vs. lowest quartile 1.83~3.70 vs. 0.21~0.76 μmol/L	12	Age, sex, SBP, HR, atrial fibrillation, acute pulmonary edema, LVEF, eGFR, Na, and BNP	Cardiac mortality	9/9
Mommersteeg, P. M. C.	2016	HF	104	66	UPLC	Continuous	Ln ADMA	73.2	Age, sex, poor exercise tolerance [6MWT<300 m] and comorbidity burden	All-cause mortality	9/9
Wang, C. H.	2016	AHF or decompensated CHF	136	58.9	UPLC	Continuous	ADMA	27.6	Age, LVEF, diabetes mellitus, eGFR, and BNP	HF-related re-ospitalization and all-cause death	9/9
Potočnjak, I.	2018	AHF	152	75.2	HPLC	Continuous	Per ADMA 1 SD increment	3 months	Age, sex, NT-pro BNP, GFR, MAP, and LDL-C	All-cause death	9/9

HPLC: high-performance liquid chromatography; UPLC: ultraperformance liquid chromatography; CHF: chronic heart failure; AHF: acute heart failure; LVEF: left ventricular ejection fraction; ICM: ischemic cardiomyopathy; DCM: dilated cardiomyopathy; eGFR: estimated glomerular filtration rate; NOS: Newcastle-Ottawa Scale criteria; ROC: receiver operating characteristic; 6MWT: Six-Minute Walk Test.