Improvement of Skeletal Muscle Regeneration by Platelet-Rich Plasma in Rats with Experimental Chronic Hyperglycemia

Table 3

Qualitative assessment of skeletal muscle regeneration.

3 days

7 days

14 days

28 days

Ctrl

CH

CH+PRP

Ctrl

CH

CH+PRP

Ctrl

CH

CH+PRP

Ctrl

CH

CH+PRP

Necrosis

+++

+++

+++

++

+++

++

–

+

–

–

–

–

Connective tissue edema

++

+++

+++

+

+++

+

+

++

+

–

+

–

Inflammatory infiltration

+++

+++

+++

+

+++

++

+

++

+

–

+

–

Vascularization

++

+

++

++

+

++

+++

++

++

+++

++

+++

Fibrosis

+

+

+

++

++

++

++

++

++

++

+++

++

CNFs

–

–

–

+

–

+

++

+

++

+++

++

+++

Ctrl: control group; CH: rats with chronic hyperglycemia; CH+PRP: rats with chronic hyperglycemia+platelet-rich plasma injection; CNFs: centrally nucleated fibers. The results are expressed as a percentage of the highest value among all groups: (–) rare or not detected; (+) between 10% and 30%; (++) between 30% and 60%; (+++) over 60%.