Identification of the Sixth Complement Component as Potential Key Genes in Hepatocellular Carcinoma via Bioinformatics Analysis

Figure 1

(a) The overall workflow of our work. (b) The data of Venn diagram about DEGs is extracted from the three GSE datasets (GSE112790, GSE87630, GSE56140). A total of 93 overlapping DEGs in the three datasets were obtained, as the following criteria: the absolute value of log and adjusted value < 0.01. (c, d) GO enrichment and KEGG pathway analysis about DEGs were presented by scatterplot. Ratio variable was demonstrated in -axis, and the terms of GO enrichment and KEGG pathway were shown in -axis. The color and size indicated the range of values and the gene number. (e) The analysis of DEGs interaction was performed by STRING and visualized with the Cytoscape software. The top 13 key genes with high degree were displayed with the first-stage nodes. Besides, the colors ranging from red, orange, to yellow represented the degree value is gradually decreased. The blue showed the first-stage nodes of other DEGs.

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