Research Article
Quality and Brands of Amoxicillin Formulations in Nairobi, Kenya
Table 5
Active pharmaceutical ingredient content results for amoxicillin/clavulanic acid dry oral suspension samples.
| | Sample code | Country of origin | Labelled active ingredients (mg/5 ml) | Chemical content as % label claim for clavulanic acid (RSD) | Chemical content as % label claim for amoxicillin (RSD) | | Day 0 | Day 7 | Day 0 | Day 7 |
| | KAN119 | India | 228 | 112.73(1.78) | 100.01(0.84) | 108.23(0.94) | 102.00(0.20) | | KBR60 | United Arab Emirates | 228 | 113.48 (0.47) | 102.20 (0.58) | 104.22(0.27) | 100.04(0.37) | | KRN93 | Canada | 457 | 98.99 (0.83) | 90.62(0.48) | 102.24(0.33) | 96.20 (0.66) | | SC05 | United Kingdom | 228 | 99.51 (0.93) | 96.18 (0.70) | 96.53 (0.68) | 90.53 (0.65) | | WST98 | India | 228 | 101.03(0.23) | 96.67 (0.48) | 91.66 (1.83) | 86.83 (0.80) | | KBR80 | India | 228 | 105.49 (1.29) | 98.34 (0.24) | 92.02 (1.25) | 88.85 (1.95) | | CBD132 | India | 228 | 116.93(0.64) | 114.64 (0.73) | 92.54 (1.33) | 89.12 (1.97) | | SC011 | France | 642.9 | 96.50(0.75) | 88.91 (0.58) | 96.90 (0.57) | 90.75 (1.15) | | KAY40 | Jordan | 642.9 | 94.43 (0.69) | 86.35 (0.87) | 94.29 (0.22) | 91.75 (0.77) | | SC08 | India | 228 | 101.70 (0.28) | 96.61 (0.21) | 82.00 (0.93) | 80.22 (0.30) | | CBD137 | India | 457 | 94.03 (1.00) | 91.30 (1.77) | 89.76(0.90) | 83.22 (1.03) | | CBD133 | India | 228 | 93.43 (0.8) | 89.93 (0.67) | 85.12 (1.63) | 82.07 (0.57) |
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RSD: relative standard deviation; USP limits: amoxicillin at ~90%-120% and clavulanic acid at 90%-125% of label claim.
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