Research Article
Quality and Brands of Amoxicillin Formulations in Nairobi, Kenya
Table 6
Active pharmaceutical ingredient and dissolution test results for amoxicillin capsules.
| | Sample code | Country of origin | Labelled active ingredients (mg) | Chemical content as % label claim (RSD) | Dissolution chemical content as % label claim (RSD) |
| | KAY52 | China | 250 | 95.91 (0.71) | 99 (3.71) | | SC10 | Kenya | 250 | 98.24 (0.26) | 99 (1.33) | | SB32 | India | 250 | 93.93 (0.27) | 97 (4.51) | | KAY56 | India | 500 | 97.08 (0.34) | 97.8 (5.3) | | KAY51 | India | 250 | 98.60 (0.66) | 95 (1.8) | | ZIM109 | Kenya | 250 | 95.98 (0.29) | 94 (5.3) | | CBD138 | Kenya | 250 | 98.12 (1.92) | 93 (3.67) | | KBR78 | China | 250 | 94.09 (1.12) | 92 (1.7) | | KAN120 | United Kingdom | 500 | 96.67 (0.63) | 100 (2.52) | | KBR87 | India | 250 | 95.06 (0.23) | 91.1(5.8) | | SC013 | India | 500 | 94.20 (0.95) | 90.70 (4.30) | | SB021 | China | 500 | 92.60 (1.64) | 88 (1.79) | | KBR67 | Kenya | 250 | 90.74 (0.55) | 88(5.3) | | KBR84 | Kenya | 500 | 94.34 (1.99) | 82.1 (3.80) | | KRN94 | Mexico | 500 | 91.94 (0.54) | 82 (5.2) | | KBR77 | Kenya | 500 | 94.78 (0.11) | 82.10 (8.3) | | CBD128 | United Kingdom | 500 | 96.57 (0.26) | 81.4(4.6) | | KAY42 | China | 500 | 94.89 (0.62) | 76.4(7.5) | | SC12 | India | 500 | 93.91 (0.46) | 75.5 (7.5) |
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RSD: relative standard deviation; USP limits: content determination at ~90%-120% and dissolution not less than (NLT) ~80% of label claim.
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