Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review

Table 1

Association sore of 155 targets associated with diabetic cardiomyopathy in heart tissue.

	Target name	Target symbol	Association score
			Data types; Known drug	Data types; Literature	Overall
1	Tripartite motif containing 55	TRIM55	0	0.177	0.177
2	Peroxisome proliferator-activated receptor alpha	PPARA	0	0.117	0.117
3	Mechanistic target of rapamycin kinase	MTOR	0.1	0.054	0.113
4	Interleukin 6	IL-6	0	0.113	0.113
5	Carnitine palmitoyltransferase 1B	CPT1B	0.1	0.000	0.100
6	Carnitine palmitoyltransferase 2	CPT2	0.1	0.000	0.100
7	Tripartite motif containing 54	TRIM54	0	0.081	0.081
8	Nuclear factor, erythroid 2 like 2	NFE2L2	0	0.072	0.072
9	Hydroxysteroid 11-beta dehydrogenase 1	HSD11B1	0	0.070	0.070
10	Fibroblast growth factor 1	FGF1	0	0.070	0.070
11	Colony-stimulating factor 3	CSF3	0	0.062	0.062
12	Beclin 1	BECN1	0	0.062	0.062
13	Cytochrome P450 family 2 subfamily J member 2	CYP2J2	0	0.061	0.061
14	Angiotensin I-converting enzyme 2	ACE2	0	0.060	0.060
15	Aldehyde dehydrogenase 2 family member	ALDH2	0	0.059	0.059
16	Glycogen synthase kinase 3 beta	GSK3B	0	0.057	0.057
17	Gelsolin	GSN	0	0.055	0.055
18	Toll-like receptor 2	TLR2	0	0.054	0.054
19	Parkin RBR E3 ubiquitin protein ligase	PRKN	0	0.054	0.054
20	Apelin	APLN	0	0.053	0.053
21	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	ST3GAL4	0	0.052	0.052
22	Peroxisome proliferator activated receptor gamma	PPARG	0	0.052	0.052
23	Corin, serine peptidase	CORIN	0	0.052	0.052
24	Titin	TTN	0	0.049	0.049
25	Angiogenin	ANG	0	0.049	0.049
26	Protein kinase D1	PRKD1	0	0.049	0.049
27	PPARG coactivator 1 alpha	PPARGC1A	0	0.048	0.048
28	Vascular endothelial growth factor A	VEGFA	0	0.048	0.048
29	Insulin-like growth factor 1	IGF1	0	0.047	0.047
30	CD36 molecule	CD36	0	0.047	0.047
31	Nitric oxide synthase 3	NOS3	0	0.046	0.046
32	Apolipoprotein A1	APOA1	0	0.044	0.044
33	Gap junction protein alpha 1	GJA1	0	0.041	0.041
34	Calsequestrin 2	CASQ2	0	0.041	0.041
35	Decorin	DCN	0	0.040	0.040
36	Urocortin	UCN	0	0.040	0.040
37	Cellular communication network factor 2	CCN2	0	0.040	0.040
38	Matrix metallopeptidase 2	MMP2	0	0.040	0.040
39	Periostin	POSTN	0	0.039	0.039
40	Fibroblast growth factor 2	FGF2	0	0.039	0.039
41	BCL6 transcription repressor	BCL6	0	0.039	0.039
42	Tax1-binding protein 1	TAX1BP1	0	0.038	0.038
43	Solute carrier family 2 member 4	SLC2A4	0	0.038	0.038
44	Rho-associated coiled-coil containing protein kinase 2	ROCK2	0	0.037	0.037
45	NADPH oxidase 4	NOX4	0	0.036	0.036
46	Mitogen-activated protein kinase 9	MAPK9	0	0.036	0.036
47	Insulin-like growth factor 2	IGF2	0	0.036	0.036
48	Angiotensin II receptor type 2	AGTR2	0	0.036	0.036
49	Lipoprotein lipase	LPL	0	0.036	0.036
50	Insulin receptor	INSR	0	0.035	0.035
51	Angiopoietin 1	ANGPT1	0	0.035	0.035
52	Interleukin 33	IL33	0	0.035	0.035
53	Caveolin 3	CAV3	0	0.034	0.034
54	Angiotensin I-converting enzyme	ACE	0	0.034	0.034
55	Patatin-like phospholipase domain containing 2	PNPLA2	0	0.034	0.034
56	ATPase sarcoplasmic/endoplasmic reticulum Ca^2+ transporting 2	ATP2A2	0	0.033	0.033
57	Glucokinase	GCK	0	0.032	0.032
58	Dimethylarginine dimethylaminohydrolase 2	DDAH2	0	0.032	0.032
59	Xenotropic and polytropic retrovirus receptor 1	XPR1	0	0.032	0.032
60	Vascular endothelial growth factor B	VEGFB	0	0.032	0.032
61	Phosphodiesterase 5A	PDE5A	0	0.031	0.031
62	MAPK-activated protein kinase 2	MAPKAPK2	0	0.031	0.031
63	Heat shock protein family E (Hsp10) member 1	HSPE1	0	0.031	0.031
64	Sirtuin 2	SIRT2	0	0.031	0.031
65	DIRAS family GTPase 3	DIRAS3	0	0.030	0.030
66	SMAD family member 3	SMAD3	0	0.030	0.030
67	Dual specificity phosphatase 5	DUSP5	0	0.030	0.030
68	Kruppel-like factor 4	KLF4	0	0.030	0.030
69	Ryanodine receptor 2	RYR2	0	0.029	0.029
70	Prohibitin	PHB	0	0.029	0.029
71	Estrogen related receptor gamma	ESRRG	0	0.028	0.028
72	Nebulin	NEB	0	0.028	0.028
73	Peroxiredoxin 3	PRDX3	0	0.028	0.028
74	Adrenoceptor beta 2	ADRB2	0	0.028	0.028
75	Solute carrier family 9 member A1	SLC9A1	0	0.028	0.028
76	Transglutaminase 2	TGM2	0	0.027	0.027
77	Poly(ADP-ribose) polymerase 1	PARP1	0	0.027	0.027
78	Insulin receptor substrate 1	IRS1	0	0.027	0.027
79	Voltage dependent anion channel 1	VDAC1	0	0.026	0.026
80	AKT serine/threonine kinase 1	AKT1	0	0.025	0.025
81	Myocyte enhancer factor 2A	MEF2A	0	0.025	0.025
82	Dual specificity phosphatase 1	DUSP1	0	0.025	0.025
83	Musculin	MSC	0	0.025	0.025
84	Diacylglycerol kinase zeta	DGKZ	0	0.024	0.024
85	Death associated protein kinase 2	DAPK2	0	0.024	0.024
86	Solute carrier family 25 member 4	SLC25A4	0	0.023	0.023
87	SMAD family member 7	SMAD7	0	0.023	0.023
88	Natriuretic peptide A	NPPA	0	0.023	0.023
89	Coiled-coil domain containing 47	CCDC47	0	0.022	0.022
90	Lipase E, hormone sensitive type	LIPE	0	0.022	0.022
91	Leptin	LEP	0	0.022	0.022
92	Arylsulfatase A	ARSA	0	0.021	0.021
93	Nitric oxide synthase 2	NOS2	0	0.021	0.021
94	Nuclear receptor subfamily 3 group C member 2	NR3C2	0	0.021	0.021
95	Sirtuin 3	SIRT3	0	0.021	0.021
96	Plasminogen	PLG	0	0.020	0.020
97	Spindlin 1	SPIN1	0	0.020	0.020
98	Serpin family E member 1	SERPINE1	0	0.020	0.020
99	Tachykinin receptor 1	TACR1	0	0.020	0.020
100	RNA binding fox-1 homolog 2	RBFOX2	0	0.020	0.020
101	Fatty acid binding protein 4	FABP4	0	0.019	0.019
102	Potassium voltage-gated channel subfamily H member 2	KCNH2	0	0.019	0.019
103	Cell adhesion molecule 1	CADM1	0	0.019	0.019
104	Prolylcarboxypeptidase	PRCP	0	0.018	0.018
105	Nucleotide-binding oligomerization domain containing 1	NOD1	0	0.018	0.018
106	Activating transcription factor 3	ATF3	0	0.018	0.018
107	Vasoactive intestinal peptide	VIP	0	0.018	0.018
108	Egl-9 family hypoxia inducible factor 3	EGLN3	0	0.018	0.018
109	Fibronectin 1	FN1	0	0.018	0.018
110	Endothelin 1	EDN1	0	0.018	0.018
111	C-C motif chemokine ligand 2	CCL2	0	0.018	0.018
112	Solute carrier family 5 member 1	SLC5A1	0	0.018	0.018
113	Fibrinogen-like 2	FGL2	0	0.017	0.017
114	Monoamine oxidase A	MAOA	0	0.017	0.017
115	Sphingosine-1-phosphate receptor 1	S1PR1	0	0.017	0.017
116	Signal transducer and activator of transcription 3	STAT3	0	0.017	0.017
117	Toll-like receptor 3	TLR3	0	0.017	0.017
118	Tripartite motif containing 63	TRIM63	0	0.017	0.017
119	TIMP metallopeptidase inhibitor 2	TIMP2	0	0.017	0.017
120	Nerve growth factor	NGF	0	0.017	0.017
121	Natriuretic peptide receptor 2	NPR2	0	0.016	0.016
122	Cyclin-dependent kinase inhibitor 1A	CDKN1A	0	0.016	0.016
123	Cathepsin D	CTSD	0	0.016	0.016
124	Thrombospondin 1	THBS1	0	0.015	0.015
125	Kinase insert domain receptor	KDR	0	0.015	0.015
126	Serine/threonine kinase 11	STK11	0	0.015	0.015
127	Enolase 3	ENO3	0	0.015	0.015
128	Gasdermin D	GSDMD	0	0.015	0.015
129	Cytochrome c, somatic	CYCS	0	0.015	0.015
130	Kallikrein B1	KLKB1	0	0.015	0.015
131	TIMP metallopeptidase inhibitor 4	TIMP4	0	0.015	0.015
132	Transforming growth factor beta 3	TGFB3	0	0.015	0.015
133	Zinc finger and BTB domain containing 16	ZBTB16	0	0.015	0.015
134	Collagen type I alpha 1 chain	COL1A1	0	0.015	0.015
135	Endothelin receptor type A	EDNRA	0	0.014	0.014
136	Cellular communication network factor 1	CCN1	0	0.014	0.014
137	Secreted protein acidic and cysteine rich	SPARC	0	0.014	0.014
138	Glucagon like peptide 1 receptor	GLP1R	0	0.014	0.014
139	Cystatin C	CST3	0	0.014	0.014
140	Intercellular adhesion molecule 1	ICAM1	0	0.014	0.014
141	Elastin	ELN	0	0.014	0.014
142	Tenascin C	TNC	0	0.014	0.014
143	PTEN-induced kinase 1	PINK1	0	0.014	0.014
144	Calpastatin	CAST	0	0.014	0.014
145	CCAAT enhancer binding protein beta	CEBPB	0	0.012	0.012
146	Acyl-coA thioesterase 1	ACOT1	0	0.012	0.012
147	G protein-coupled bile acid receptor 1	GPBAR1	0	0.010	0.010
148	Annexin A1	ANXA1	0	0.010	0.010
149	Apolipoprotein L2	APOL2	0	0.008	0.008
150	Natriuretic peptide B	NPPB	0	0.008	0.008
151	Leptin receptor	LEPR	0	0.008	0.008
152	Serum response factor	SRF	0	0.008	0.008
153	Heat shock protein family B (small) member 3	HSPB3	0	0.007	0.007
154	Angiotensin II receptor type 1	AGTR1	0	0.007	0.007
155	Protein phosphatase 5 catalytic subunit	PPP5C	0	0.007	0.007