S100A9 Increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-Like Cells

<div>Effect of S100A8, S100A9, and <i>Pg</i> LPS on cell viability of osteocytes. When MLO-Y4-A2 cells reached subconfluence, cells were treated with S100A8 (10–50 nM), S100A9 (10–50 nM), and <i>Pg</i> LPS (500 ng/ml) for 48 hours, and cell viability was analyzed using CCK-8. Data are means ± SD and expressed as a percent of control (<i>n</i> = 5). N.S indicates no significant difference between the indicated groups and control group.</div>

BioMed Research International

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Figure 1

Figure 1: S100A9 Increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-Like Cells 