IFN-γ Mediates the Development of Systemic Lupus Erythematosus
Table 2
Top 10 hub genes with high degree of DEGs in SLE.
Gene symbol
Full name
Function
Degree
STAT1
Signal transducer and activator of transcription
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF, and other cytokines and other growth factors. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein homodimerization activity.
54
IRF7
Interferon regulatory factor
Key transcriptional regulator of type I interferon- (IFN-) dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity.
50
MX1
MX dynamin-like GTPase 1
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity.
49
OASL
2-5-Oligoadenylate synthetase-like
Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding.
49
ISG15
ISG15 ubiquitin-like modifier
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. Gene Ontology (GO) annotations related to this gene include protein tag.
48
IFIT3
Interferon-induced protein with tetratricopeptide repeats 3
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Gene Ontology (GO) annotations related to this gene include identical protein binding.
47
IFIH1
Interferon induced with helicase C domain 1
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity.
47
IFIT1
Interferon-induced protein with tetratricopeptide repeats 1
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Gene Ontology (GO) annotations related to this gene include RNA binding.
46
OAS2
2-5-Oligoadenylate synthetase 2
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Gene Ontology (GO) annotations related to this gene include RNA binding and transferase activity.
46
GBP1
Guanylate binding protein 1
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Gene Ontology (GO) annotations related to this gene include identical protein binding and enzyme binding.
