Antioxidant Effects and Cytoprotective Potentials of Herbal Tea against H₂O₂-Induced Oxidative Damage by Activating Heme Oxygenase1 Pathway

Figure 6

Transcriptomic alterations in 2BS cells upon different treatments by vehicle (control), H₂O₂, and Wanglaoji herbal tea (WHT). (a) Volcano plot of significant and nonsignificant differentially expressed genes upon different treatments (red or blue colors indicates the up- and downregulated genes, respectively); (b) Venn diagram comparison of H₂O₂ treatment vs. control and WHT treatment vs. H₂O₂ treatment; (c) significant molecular and cellular function identified by Ingenuity Pathway Analysis (IPA) software; (d) significant canonical pathway identified by IPA software. (e) Frequency analysis of differentially expressed genes from enriched signaling pathway; (f) Venn diagram comparison of the genes which were regulated by WHT in the same direction by regulators from the mechanism network of genistein and opposite direction by regulators from the mechanism network of H₂O₂ by an upstream regulator analysis tool of IPA.

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