Effect of a DPP-4 Inhibitor on Orthodontic Tooth Movement and Associated Root Resorption

Figure 3

Evaluation of odontoclast activity and root resorption on the transverse histological sections. (a) TRAP-stained histological sections of the distobuccal root of the maxillary left first molar before and after 12 days of experimental tooth movement with administration of PBS or 30 μg of DPP-4 inhibitor. Arrows represent the direction of orthodontic tooth movement. (b) The number of TRAP-positive multinuclear cells in mice along the root surface on the mesial side. for each group. ; . (c) The evaluation of the root resorption surface with histological sections. Solid line indicates the root surface, and the interrupted line indicates the resorption surface. The root resorption surface was measured by the percentage of interrupted line/solid line. . (d) The ratio of the root resorption surface in control group and experimental groups treated with PBS or DPP-4 inhibitor. for each group. ; .

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